Classification based on biosynthetic pathway & surface assembly


Properties Group-1 Group-2 Group-3 Group-4
Type of polysaccharide Acidic polysaccharides (Uronic acids) Repeat units vary extensively Repeat units vary Acidamido sugars
Occurence Found in isolates that cause intestinal infections Found in isolates that cause extraintestinal infections Found in isolates that cause extraintestinal infections Found in isolates that cause intestinal Infections
Co-expression with colanic acid Absent Present Present Present
Terminal lipid moiety KLPS-Lipid A K Ag-unknown α glycerophosphate α glycerophosphate KLPS-Lipid A K Ag-unknown
Polymer grows at Reducing terminus Nonreducing terminus Nonreducing terminus Reducing terminus
Polymerization type Wzy dependent ABC transporter dependent ABC transporter dependent Wzy dependent
Serotypes

K26, K27, K28, K29, K30

K31, K32, K33, K34, K35

K36, K37, K39, K42, K55

K102, K103

K1, K2a, K2ab, K4, K5, K6

K7, K12, K13, K14, K15

K16, K18, K19, K20, K22, K23

K24, K51, K52, K53, K74

K92, K93, K95, K97, K100

K3, K10, K11, K54, K96, K98

K8, K9, K38, K40, K44, K45, K46

K47, K48, K49, K50, K57, K83, K85

K87, O111, K101

Capsular similarity Klebsiella, Erwinia Neisseria, Haemophilus Neisseria, Haemophilus None
Gene locus CPS locus near his KPS near ser A KPS near ser A Near his and 22-minute locus (Homologs of wza,wzb,wzc present)

WHITFIELD, C. & ROBERTS, I. S. 1999. Structure, assembly and regulation of expression of capsules in Escherichia coli. Mol Microbiol, 31, 1307-19.

WHITFIELD, C. 2006. Biosynthesis and assembly of capsular polysaccharides in Escherichia coli. Annu Rev Biochem, 75, 39-68.


© Indian Institute of Technology Hyderabad, India
TR Lab, Department of Biotechnology, Indian Institute of Technology Hyderabad, India